摘要
一氧化氮(NO)在宿主抗疟原虫感染的免疫应答过程中发挥重要作用。通过CO8+T细胞、NK细胞的介导,NO可有效地控制红外期疟原虫的感染。在抗红内期疟原虫感染的免疫应答中,由于感染宿主的免疫状态、感染虫株的差异性以及疟原虫的发育阶段和NO产生部位不同等多种因素的影响,NO生物学作用的发挥存在一定差异。当疟原虫进入蚊发育阶段,NO则能够有效地阻断配子体的感染力及杀灭动合子。
Nitric Oxide （NO） plays a critical role in the host immunity against plasmodium infection. NO can effectively control infection with exoerythrocytic stage plasmodium, which mediated by CD8^＋ T, NK cell. During immunity against blood-stage plasmodium, the differences in hosts of immune states, Plasmodium species, development stages of plasmodium and NO secretion status can result in differences in NO biological action. When plasmodium develops in the mosquito, NO can block gametocytes infectivity and kill ookinetes.
出处
《寄生虫与医学昆虫学报》
CAS
2005年第3期185-188,共4页
Acta Parasitologica et Medica Entomologica Sinica
