体感诱发电位在脑通口服液治疗大鼠急性脑梗死中的应用

Effects of Naotong oral solution on acute cerebral infarction in rats

目的观察脑通口服液(NT)对急性脑梗死大鼠体感诱发电位(SEP)的影响及其疗效.方法 24只脑梗死模型大鼠随机分为3组,分别用NT、脑血康口服液(NXK)和生理盐水(NS)灌服治疗20 d,于治疗前后观察动物的SEP和神经病学评分改变.结果与治疗前比较,NT组大鼠所有SEP波及NXK组部分SEP波潜伏期缩短( P<0.01);NT和NXK组大鼠治疗后神经病学评分均降低( P<0.05),且低于NS对照组组 ( P<0.05);模型大鼠SEP潜伏期与神经病学评分呈高度正相关( r=0.97～0.99; P<0.05～0.01).结论脑通口服液可明显促进急性脑梗死大鼠神经功能的恢复;SEP可用于急性脑梗死的疗效观察.

Objective To observe effects of Naotong （NT） oral solution on the somatosensory evoked potentials （SEP） of acute cerebral infarction rats and its curative experimental. Methods 24 model rats were randomly divided into three groups and treated with NT oral solution, Naoxuekang （NXK） and normal saline （NS） respectively for 20 days, the SEP and neurologic grades of the rat models were evaluated before and after treatment. Results All the latencies of SEP （P1, N2, P2 ） in NT group was shorter than that of the pre-treatment and NS control group （ P〈0.01）. The neurologic grades of both NT and NXK groups were highly lowered compared with pre-treatment and NS control group （both P〈0.05）. The latencies of SEP in the model rats were highly correlated with the neurologic grades （ r =0.97～0.99, P〈0.05～0.01）. Conclusion NT can accelerate the nervous function recovery of the rat models with acute cerebral infarction. SEP may be used as a powerful index of observation on curative effect of acute cerebral infarction.