妊娠中期CRP、激活素A等水平与IUGR关系的研究

Study of the relationship between CRP,activin Aetc and IUGR

目的通过测定孕中期母血清CRP、激活素A、高半胱氨酸、MPO、PMN弹性蛋白酶水平,探讨其与IUGR的关系。方法选取孕周为19-24w的孕妇共69例,其中21例为IUGR组,48例为对照组,CRP、激活素A、高半胱氨酸、MPO、PMN弹性蛋白酶的测定采用ELISA法。结果IUGR组激活素A、高半胱氨酸水平高于对照组(P<0.05),CRP明显升高(P<0.01);MPO、PMN弹性蛋白酶无明显差异(P>0.05)。结论孕中期母血MPO、PMN弹性蛋白酶与IUGR无明显关系,激活素A、高半胱氨酸升高,CRP明显升高,因此孕中期检测母血中CRP、激活素A、高半胱氨酸水平可预示IUGR的发生,为IUGR的早期诊断和治疗提供重要的理论依据。

Objective： To explore the relationship between CRP, aetivin A, homocysteine, MPO, PMN elastase and fetal growth through measuring their concentration in matemal blood. Methods： Choosing 69 pregnancy women, of which IUGR group 21, control group 48. Their pregnancy age were 19- 24 weeks. CRP, activin A, homocysteine, MPO,PMN elastase levels were measured by ELISA. Results： Contrasted with control group, the levels of activin A, homocysteine increased in IUGR group （ P 〈 0.05）, the levels of CRP increased significantly （ P 〈 0. 01 ）, and the levels of MPO, PMN elastase has no difference between the two groups （ P 〈 0.05）. Conclusion： MPO, PMN elastase have no relationship with IUGR. activin A, homocysteine , CRP had close relationship with IUGR. Detecting their levels in maternal blood during the second trimester pregnancy could afford important theoretical evidence for the earlier diagnoses and trentment of IUGR.