癫痫患者脑脊液中TNF-α、IL-6含量变化及意义

The changes and significance of Tumor Necrosis Factorα and interleukin-6 in cerebrospinal fluid from epileptic patients

目的探讨肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)与癫痫免疫学发病机理的关系。方法采用放射免疫测定法检测64例癫痫患者和38例正常对照组脑脊液(CSF)中TNF-α和IL-6的含量。结果癫痫组TNF-α和IL-6含量均明显高于对照组(P<0.01),不同发作类型癫痫患者CSF中TNF-α和IL-6的含量差异无显著性,相关分析发现癫痫患者CSF中TNF-α与IL-6含量之间呈显著正相关(r=0.712,P<0.01)。结论TNF-α和IL-6可能共同参与癫痫的免疫学发病机理。

Objective To study the relationship among tumor necrosis factor-α （TNF-α）, interleukin- 6 （ IL- 6） and the immunologic pathogenesis of epilepsy. Methods A radioimmunoassay （RIA） method was used to detect the levels of TNF-α and IL- 6 in the cerebrospinal fluid （CSF） from sixty- four patients with epilepsy （the epilepsy group） and thirty-eight healthy individuals （the control group）, respectively. Results The levels of TNF-α and IL- 6 in the epilepsy group were higher than those in the control group, there were statistically signifi- cant differences, P 〈 0.01. In comparison among different attack types, there were no statistically significant differences in TNF-α and IL - 6. The correlation analysis suggested that there was a positive correlation between TNF-αand IL-6 （ r = 0.712, P 〈0.01） pathogenesis of epilepsy. Conclusion TNF -α and IL- 6 may be involved in the immunologic