血清IL-6和IL-8在还原型谷胱甘肽治疗肝硬化患者前后的变化

Study on the relationship between interleukin-6 and interleukin-8 levels and the prognosis in patients with liver cirrhosis

目的探讨肝硬化患者血清白细胞介素6(IL-6)、白细胞介素8(IL-8)水平变化的临床意义。方法采用ELISA法测定肝硬化患者治疗前后血清IL-6和IL-8水平。结果36例肝硬化患者血清IL-6I、L-8水平较正常对照组显著增高。采用还原型谷胱甘肽治疗一个月后肝功能恢复者血清IL-6I、L-8水平较治疗前显著降低,而肝功能未恢复者血清IL-6I、L-8水平较治疗前降低不明显。结论肝功能损伤可能是白细胞介素活性增加的重要原因,细胞因子的水平与肝硬化的形成及预后有关,还原型谷胱甘肽具有一定的治疗作用。

Objective To investigate the changes and clinical significanees of interleukin-6 and interleukin-8 on prognosis in patients with liver cirrhosis. Methods The serum levels of cytokines were measured by ELISA in patients with liver cirrhosis and in control group. Results The serum levels of IL-6 and IL-8 in patients with liver cirrhosis were significantly higher than in control group . Serum levels of IL-6 and IL-8 were significantly decreased in patients with restored hepatic function test after glutathione therapy. Condusion Liver dysfuntion maybe the reason of interleukin -6 and IL-8 elevation in patients with liver cirrhosis. Glutathione may have some curing role on liver cirrhosis.