六种方案治疗慢性乙型肝炎1363例临床观察

Clinical observation on six schedules in treatment of 1363 patients with chronic hepatitis B

目的回顾性分析甘草酸二胺(第5组)、单胺(第6组)、山莨菪碱(第2组)、门冬氨酸钾镁(第3组)、山莨菪碱+门冬氨酸钾镁注射液(第4组)及口服茵黄片(第1组)治疗慢性乙型肝炎患者的疗效.方法慢性乙型肝炎1363例,甘草酸二胺150mg、单胺40ml、山莨菪碱10mg、门冬氨酸钾镁20ml分别加入5%～10%葡萄糖注射液250ml中静脉滴注,茵黄片口服,治疗结束后进行疗效分析.结果慢性乙型肝炎患者的临床治愈率为93.1%.5、6组患者的平均住院日、ALT复常时间为42.0、43.9,35.5、36.2天,较其他组缩短18～44、5～17.7天,较1、2组患者缩短7～9天,乏力、肝区叩痛消失时间为17.5、18.0,16.0、15.2天,较1、2、3组患者缩短5～8,9～12天,肝区不适消失时间为14.5、16.1天,较1组患者缩短16～18天(P＜0.05～0.01).结论在治疗慢性乙型肝炎时,甘草酸二胺、单胺在改善患者临床症状和肝功能指标方面优于茵黄片、山莨菪碱和门冬氨酸钾镁,该两种药物在治疗慢性乙型肝炎中疗效相当.口服茵黄片的疗效低于静脉应用药物.

Objective To analyze retrospectively the effect of diammonium glycyrrhizinate （the fifth group）, glycyrrhizinate（the sixth group）, anisodamine injection（ the second group）, potassium megneium aspartate panangin injection （the third group）, anisodamine plus potassium megneium aspartate panangin injection （the fourth group）, yinhuang tabllet （the first group） in treat- ment of patients with chronic hepatitis B. Methods 1363 patients with chronic hepatitis B were treated with 150mg diammonium panangin injection,40ml monoammonium glycyrrhizinate, 10rag anisodamine injection, 20ml potassium megneium aspartate pangagin injection added into 250ml of 5 % to 10% glucose respectively, or treated with yinhuang tablets for 40 ～ 100days. Results The average hospitalization duration, the recovery duration of ALT in the fifth and sixth group were 42.0 days, 43.9 days, 35.5 days, 36.2 days respectively. They were shortened for 18 ～44 days, 5 ～ 13 days than other groups. The disappearance of poor appetite, abdominal distension, yellow urine were 16.0 days, 14.7 days, 15.1 days, 15.6 days, 18.1 days, 17.7 days respectively.They were shortened for 7 ～9 days than the other groups. The disappearance of hepatie region discomfort was 14.5 days, 16,1 days respectively, which was shortened for 16 ～ 18 days than the first group （ P 〈 0.05 ～ 0.01 ）. Conclusion Monoammonium glycyrrhizinate, diammonium giycyrrhizinate are superior to inhuang tablet, anisodamine injection, potassium megneium aspartate panangin injection in treating the patients with chronic hepatitis B.