特殊人群血清尿酸分布特点及与其他心血管危险因素关系

Study of serum uric acid distribution and association with other cardiovascular disease risk factors among a specific population

目的调查城乡结合部中老年居民血清尿酸的分布特点,高尿酸血症患病情况及与其它心血管危险因素的关系。方法对广州城乡结合部石牌村现居住村民进行调查, 以该人群中55岁以上男女性642人为研究对象,对血清尿酸及其它多项心血管危险因素进行统计分析。结果①血清尿酸水平男性(357.30±66.77)μmol/L,女性(299.80±59.64)μmol/L,高尿酸血症患病率男性30.26%,女性30.82%;②男性尿酸水平高于女性(P<0.001);③血清尿酸与总胆固醇、甘油三酯、血压及体重指数正相关,与高密度脂蛋白负相关;④各种心血管危险因素在该人群中有聚集现象。结论血清尿酸升高可能是心血管及代谢性疾病的重要标志。该人群高尿酸血症及其它心血管危险因素的检出率高于一般人群,检出高危人群并进行相应干预治疗有重要价值。

Objective To study serum uric acid distribution and association with other cardiovascular disease risk factors among a specific population. Method Six hundred and forty two middle-aged and elderly Cantonese in Shipai village,which is the conjoining area between city and countryside in Guangzhou,were tested for serum uric and other cardiovascular disease risk factors. Result ①Serum uric acid level in men was （ 357.30±66. 77）μmol/L, while （ 299.80±59.64）μmol/L in women. The prevalence of hyperuricemia was 30. 26% in men,and 30. 82% in women.②Serum uric acid level was higher in women than in men （P 〈 0. 001）. ③Total cholesterol, triglyceride, blood pressure and body mass index were positively associated with hyperuricemia,while high-density lipoprotein cholesteral was negtively correlated with uric acid. ④There was aggregation of variable cardiovascular risk factors in this population. Conclusion It is indicated that the elevation of serum uric acid may be an important sign of cardiovascular diseases and metabolic diseases. The rates of cardiovascular risk factors in this population are higher than people in general and relevant interventions are significantly valuable for those population.