摘要
目的探讨抗HBV特异性主动免疫疗法(主动免疫)和干扰素(IFN)联合使用,观察其抗乙型肝炎病毒的效果.方法应用前瞻性随机分组的方法,对180例未经治疗的慢性乙型肝炎患者分3组进行观察,每组60例,A组:(主动免疫联合IFN),主动免疫每月1次,α-1b-IFN 5MU,每周3次;B组:α-1b-IFN 5MU,每周3次;C组:对照组.总疗程为12个月.分别于治疗后第3、6、9、10、11、12个月和随访半年时抽血检查,并观察各组HBV DNA复制水平、HBeAg、肝功能变化.结果A组有显著的抗病毒效果,显著高于B组和C组,直至治疗结束后6个月,均显示出极好的抑制HBV复制和持续的丙氨酸氨基转移酶复常效果(34.0±11.4)U/L对(86.4±31.4)U/L,P＜0.01.A组与B组比较,治疗结束6个月,病毒负荷量(11.02±1.52)×105copies/ml对(77.98±3.12)×105 copies/ml,P＜0.01,差异有显著性.结论抗HBV特异性主动免疫疗法联合α-1b干扰素的应用,具有显著增加抗病毒效果,特别是停药后持续抗病毒及肝功能持续正常的疗效更为显著.
Objective To explore a new anti-virus therapy for HBV infection. Methods A total of 180 patients with chronic hepatitis B （CHB） were randomized into 3 groups. Each group of patients was either treated with interferon alpha lb（IFN）, anti-HBV specific active immunity in combination with interferon（combination group） or no anti-virus therapy （control group） for 12 months. The serum samples were collected at 3rd, 6th, 9th, lOth, 1 lth, 12th and 18th month after the treatments and assayed for ALT, HBeAg, HBV DNA （quantitative PCR）. Results The anti-virus replication effects were significantly higher in the combination group than in the IFN and control groups （P〈0.01）. The significant and persistent inhibitory effects on HBV replication and improvement of liver function were found. It was more effective than IFN treatments at the end of the drug administration and 6 months later after the drug was withdrawn （P〈0.01）. Conclusions This method of anti-HBV specific active immunity in combination with interferon administration can significantly improve the anti-virus effects on HBV replication and prevent the rebound of HBV after drug withdrawal.
出处
《传染病信息》
2005年第3期131-133,共3页
Infectious Disease Information
