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异基因移植CD56^+ CD16^+量对移植物抗宿主病影响

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摘要 目的探讨异基因外周血干细胞移植供者CD56+CD16+细胞的量对移植物抗宿主病(GVHD)的影响。方法对16例白血病患者应用HLA配型完全相合同胞供者进行了外周血干细胞移植,并观察了输注CD16+、CD56+量与GVHD的关系。结果16例患者均早期获得了造血功能恢复,4例发生了Ⅰ度aGVHD,5例发生了Ⅱ度aGVHD,输注CD16+、CD56+细胞的绝对量与Ⅱ度aGVHD发生呈负相关,相关系统为-0.67,Ⅱ度aGVHD所输注CD3+细胞绝对值、CD34+细胞绝对值无明显相关性。结论异基因外周血干细胞移植GVHD的发生与输注CD16+、CD56+细胞的绝对量相关。
作者 朱尊民 张琳 张鲁芳 郭建民 张茵
机构地区 河南省人民医院血液科
出处 《医药论坛杂志》 2005年第20期36-37,共2页 Journal of Medical Forum
关键词 异基因 造血干细胞 移植 GVHD 移植物抗宿主病 异基因外周血干细胞移植 异基因移植 CD56^+细胞 AGVHD CD34^+细胞
分类号 R457.7 [医药卫生—治疗学] R733.72 [医药卫生—肿瘤]
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参考文献6

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二级参考文献12

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医药论坛杂志
2005年 第20期

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