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盐酸曲马多的合成 被引量:1

Synthesis of Tramadol hydrochloride
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摘要 间溴苯甲醚与2-二甲胺甲基环己酮反应,在一定的条件下制备得到1-间甲氧苯基-2-二甲胺甲基环己醇的顺反异构体的混合物,对其分离得到相应地反式异构体——盐酸曲马多。 The reaction of m-bromoanisole with 2-(dimethylaminomethyl)cyclohexanone yielded the title as a mixture of Z- and E-isomers,which were separated into tramadol.
出处 《河北化工》 2005年第5期36-36,78,共2页 Hebei Chemical Industry
关键词 盐酸曲马多 间溴苯甲醚 2-二甲胺甲基环己酮 合成 分离 tramadol m-bromoanisole 2- (dimethylaminomethyl) cyclohexanone synthesis separation
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