两种短程三联疗法治疗儿童幽门螺杆菌感染疗效评价

Evaluation of two different triple therapies on helicobacter pylori infection in children

目的:评价两种三联疗法对儿童幽门螺杆菌(Hp)感染的疗效。方法:采用13C尿素呼吸试验(13C-UBT)确诊为Hp感染的患儿85例,随机分为A组45例,B组40例。A组予阿莫西林-克拉维酸、克拉霉素和奥美拉唑,疗程1周;B组予阿莫西林、克拉霉素和奥美拉唑,疗程2周。结果:A、B组Hp根除率分别为93.3%和92.5%,临床症状缓解率、3个月后13C-UBT阳性率亦无显著性差异(P>0.05)。结论:阿莫西林克拉维酸、克拉霉素和奥美拉唑疗程1周的三联疗法是治疗儿童HP感染简单、经济、有效的治疗方法。

Objective： To evaluate the therapeutic effects of two different triple therapies on helicobacter pylri （Hp） infection in children. Methods： Eighty-five Hp infectious children confirmed by rising ^13C-UBT were randomly divided into group A and group B. Group A was given amoxicillin-clavulantic acid, clarithromycin and omeprazole for one week while the group B was given the same dosages of amoxicillin, clarithromycin and omeprazole for two weeks. Results： HP eradication rate in group A was 93.3% and in group B was 92.5%, the positive rate of ^13C-UBT in group A was 2/33 3 months after treatment completed and that in group B was 2/27. There was not significant difference between the two groups （P 〉 0.05）. Conclusions： The triple therapy composed of anloxicillin-clavulantic acid, clarithromycin and omeprazole for one week was simple and effective in eradicating HP infection in children.