头孢克肟分散片的溶出度考察

The dissolution research of the dispersible tablet of cefixime

目的:对市售头孢克肟分散片和胶囊进行溶出度比较。方法:按中国药典2005版溶出度检查方法(转篮法),用紫外分光光度法测定其含量,测定波长为287 nm。结果:头孢克肟分散片和胶囊在5 min时的累计溶出度分别为(60.22±0.5)%和(51.52±2.4)%;在10 min时的累计溶出度分别为(95.33±0.8)%和(88.67±2.7)%。结论:头孢克肟分散片具有较快的溶出速率。

Objective： To compare the dissolution of the dispersible tablet and the capsule of cefixime. Method： The dissolutiola test approved by Chinese pharmacopoeia 2005 edition was used. Ultraviolet spectrophotometry was used for the quantitative analysis of ecfixime. Results： The dissolutions of the dispersible tablet and the capsule were （60.22±0.5）% and （51.52±2.4）% in 5 min, （95.33±0.8）% and （88.67±9.7）% at 10 min. Conclusion： The dissolution of the dispersible tablet is more rapid.