雾化吸入布地奈德预防急性上感诱发婴幼儿喘息的临床研究

Clinical study on inhalation of budesonide in preventing infant wheezing after acute upper respiratory infection

目的:探讨雾化吸入布地奈德预防急性上呼吸道感染(AURI)诱发婴幼儿喘息的临床效果。方法:将既往有毛细支气管炎病史的AURI患儿126例随机分成两组,对照组63例采用常规治疗,治疗组63例在常规治疗的基础上加用布地奈德雾化治疗,统计两组出现喘息性征象和诱发喘息性疾病的病例数。结果:治疗组出现喘息性征象和诱发喘息性疾病的病例数均明显少于对照组(P<0.01)。结论:雾化吸入布地奈德预防AURI诱发婴幼儿喘息疗效确切,方法简便,副作用小,值得临床推广。

Objective： To explore the therapeutic efficacy of inhalation of budesonide in preventing infant wheezing after acute tipper respiratory infection （AURI）, Methods： 126 cases of AURI with bronchiolitis history were divided randomly into 2 groups： control group （n=63） treated with tradition therapy and treatment group （n=63） treated with budesonide besides tradition therapy, then the numbers of cases with asthmatic signs and asthmatic diseases after AURI were counted in two groups. Results： The cases with asthmatic signs and asthmatic diseases in treatment group were obviously fewer than those in control group （P 〈 0.01）. Conclusion： Inhalation of budesonide is really efficacous in preventing infaut wheezing after AURI, with less side effect and easy operation, and is worth clinical application.