低分子肝素钙预防过敏紫癜肾炎疗效观察

The precautionary effect of low molecule heparin calcium in anaphylactoid purpurd nephritis

目的:探讨低分子肝素钙对儿童紫癜肾炎的预防效果。方法:治疗组在对照组基础上加用低分子肝素钙10 iu/(kg.d)皮下注射,疗程7 d,观察尿MA及1α-MG的变化及两组紫癜合并肾损害发生率的变化进行。结果:治疗组与对照组相比其MA及1α-MG在治疗后1个月、6个月均低于对照组有显著性差异(P<0.01),治疗组合并肾损害发生率明显的低于对照组有显著性差异(P<0.01)。结论:低分子肝素钙对儿童紫癜肾炎预防效果明显,使用安全。

Objective： To investigate the precautionary effect of low molecule heparin calcium in children＇s purpurd nephritis. Methods： In addition to what were administrated in control group, the low molecule heparin calcium 10 iu/（kg·d） was given to the treatment group for seven days. Urine MA α1-MG and the rate of renal impairment were observed in the two groups. Results： Between the remedy group and the control group, the effects of MA and α1-MG were significantly different after treating one month and six months （P 〈 0.01 ）. Nephritis impairment incidence of remedy group was far lower than that of control group （P 〈 0.01 ）. Conclusion： The low molecule heparin calcium in children＇s purpurd nephritis is effective and safe.