纳络酮和苯巴比妥合用预防新生儿重度窒息后脑损伤

Naloxone in preventing brain injure after severe asphyxia in newborn

目的:观察纳络酮预防新生儿重度窒息后脑损伤的效果。方法:将新生儿重度窒息复苏后患儿45例随机分为对照组和治疗组。对照组在生后6 h内单用苯巴比妥,治疗组则在使用苯巴比妥的基础上加用纳络酮,比较两组惊厥发生率和出生后24￣72 h颅脑CT显示脑损伤的差异。结果:两组在控制惊厥的发生率上无明显差异,但在降低脑损伤的发病率上具有显著性差异。结论:对于新生儿重度窒息复苏后患儿应尽早联合使用纳络酮和苯巴比妥,能有效的预防缺氧性的脑损伤。

Objective： To observe the effect of naloxone in preventing brain injure after severe asphyxia in newborn, Method： 45 revived patients from severe asphyxia of newborn were divided into 2 groups randomly, The controlled group was applied only with phenobarbital in 6 h, and the treatment group with phenobabital and naloxone, The differences of convulsion incidence and that of brain injure shown through CT 24 - 72 h after delivery, were compared, Results： The effect of 2 groups in controlling convulsion had no significant difference, But brain injure incidence in the treatment group was lower than that of the controlled group, Conclusion： It is necessary to use naloxone to prevent brain injure after severe asphyxia in newborn.