糖尿病患者血清1,5-脱水葡萄糖醇的变化及临床价值

The change and evaluation of serum 1,5-anhydroglucitol level in patients with diabetes millitus

目的评价血清1,5-脱水葡萄糖醇与糖化血清蛋白水平变化的临床意义。方法对125例健康人和83例非胰岛素依赖型糖尿病(NIDDM)患者,采用吡喃氧化酶(PROD)法测定1,5-AG;酮胺氧化酶(KAO)法测定糖化血清蛋白(GSP)。结果NIDDM患者血清AG含量(30.1±11.6μmol/L)明显低于健康对照组(179.3±49.2μmol/L),GSP含量(328±29.6μmol/L)明显高于对照组(179±28.5μmol/L)。患者血清AG含量与空腹血糖(FBG)及GSP呈明显负相关(γ值分别为-0.425和-0.236,P值分别<0.01和0.05)。AG和GSP对糖尿病诊断的敏感性分别为93.8%和82.1%。结论结果提示血清AG含量测定可做为糖尿病诊断,筛选和血糖控制监测的指标。

Objective To evaluate the significance of the changes of serdm 1,5-anhydroglucitol （AG） and glueosylated serum protein （GSP） levels. Methods 1,5-AG was measured by pyran oxydase （PROD） method and GSP was measured by ketoamine oxidase（KAO） method in 125 healthy subjects and 83 patients with non-insulim-dependent diabetes mellitus（NIDDM）. Results The resuits showed that serum 1,5-AG level in NIDDM was 30.1±11.6μmol/L, significantly lower than that in healthy subjects （179.3 ± 49.2μmol/L）, GSP level was 386 ± 29.6 μmol/L, singificantly higher than that in healthy subjects （179 ± 28.5 μmoFL）; The serum 1,5-AG concentration in DM was negatively correlated with fasting blood glucose （r=-0.425,P 〈 0.01） and GSP （r=-0.236, P 〈 0.05） respectively. The sensitivities of serum 1,5-AG and GSP measurements in DM are sepa- rately 93.8% and 82.1%. Conclusions These finding indicated that serum 1,5-AG can be an useful indicator in the diagnosis and screening of DM as well as in monitoring blood glucose level.