血瘀证患者血小板α—颗粒膜蛋白、内皮素测定

Determination of Platelet-Granular Membranous Protein and Endothelin in Blood Stasis Patient

本文以血小板α-颗粒膜蛋白(GMP—140)及内皮素(ET)为血小板活化、内皮细胞功能受损的指标。观察病种为心血管疾病、肾脏病及Ⅱ型糖尿病。结果显示:3种疾病组的血浆GMP—140、ET皆明显高于正常对照组(P<0.01及<0.001)。证实上述3种疾病组中存在着血小板活化及血管内皮细胞受损现象,并发现3种疾病中的血瘀证患者其GMP—140、ET值升高尤为明显,其值均显著高于无血瘀证患者。

Platelet a - GMP - 140, ET were used as indices of activation of platelet, functional injury to endothelial cells. Cardiovascular diseases, nephropathy and II type diabetes were selected forobservation. Results showed that the plasmal GMP-140 and ET were all markedly higher than that of the controlled group (P <0. 01 and <0. 001) , demonstrating that there are injuries to the activation of platelet and vascular endothelial cells. It was also found that inpatients with blood - stasis syndrome in the above 3 kinds of diseases, the increase of GMP-140, ET values were even more conspicuous, with markedly increased values as compared with that of patients without blood stasis.