氧氟沙星的体外抗菌试验

The antihacterial activity test of ofloxacin in vitro

检测了７种２２６株常见临床感染菌及９种１５４株化脓性皮肤病临床验证分离菌对氧氟沙星（ＯＦＬＸ）、诺氟沙星（ＮＦＬＸ）、红霉素、氯霉素、庆大霉素的敏感性。结果表明ＯＦＬＸ体外抗菌的ＭＩＣ＿(５０)和ＭＩＣ＿(９０)分别为０．７２及７．４６μｇ／ｍｌ，而红霉素、氯霉素及庆大霉素均呈不同程度耐药。ＯＦＬＸ与ＮＦＬＸ对临床验证分离的１５４株化脓菌的ＭＩＣ＿(５０)和ＭＩＣ＿(９０)分别为０．２７，１．９３μｇ／ｍｌ及０．７，０μｇ／ｍｌ。ＯＦＬＸ较ＮＦＬＸ强２～４倍。

he sensitivities of ofloxacin (OFLX), nofloxacin(NFLX) ,erythromycin,chioromycetin ,gentamycin were ex-amined for 7 category 226 common clinical infectious strains and 9 category 154 flinical evaluated strains. TheMIC50 and MIC90 of OFLX for 226 common clinical infectious strains is 0. 72, 7. 46μg/ml respectively, but ery-thromycin,chloromycetin,gentamyc are medicines-resistant in various degrees. The MIC50, MIC90 of OFLX andNFLX for 154 clinical evaluated strains is 0. 27, 1.93μg/ml and 0. 7, 6. 3μg/ml respectively. The antibacterial activi-ty of OFLX is 2￣4 times higher than NFLX.