摘要
以L-组氨酸为起始原料,设计合成了含组氨酸残基的手性肽核酸单体.以叔丁氧羰基(Boc)保护α-氨基,羧基形成苄酯加以保护,分别以苄氧羰基(Cbz)及2,4-二硝基苯基(Dnp)作为咪唑基的临时和永久保护基,共九步反应,手性肽核酸单体总收率13.3%.
A chiral PNA monomer containing histidine residue has been designed and synthesized in 9 steps with an overall yield 13.3%. The protecting groups of a-amine, carboxyl, and imidazole are t-butyloxocarbonyl, benzyl, and benzyloxocarbonyl, respectively. The final protecting group of imidazole is 2,4-dinitrofluorobenzenyl （Dnp）.
出处
《烟台大学学报（自然科学与工程版）》
CAS
2005年第4期287-292,共6页
Journal of Yantai University(Natural Science and Engineering Edition)
关键词
肽核酸单体合成
组氨酸
保护策略
2
4-二硝基苯基
peptide nucleic acid monomer synthesis
histidine
protecting tactics
2,4-dinitro-benzenyl
