银屑病患者血浆β-内啡肽测定及其临床意义

Detection of Serum Beta endorphin and its Clinical Significance in Patients with Psoriasis

为了探讨β－内啡肽（β－ＥＰ）在银屑病发病中的作用机理，采用放射免疫分析法对５１例银屑病患者外周血β－ＥＰ水平进行了检测，并与３２例健康体检者对照。结果显示：银屑病患者血浆β－ＥＰ水平明显高于对照组，即使达到临床治愈时，β－ＥＰ水平有所下降，但仍高于对照组；发病前有诱因者较无诱因者β－ＥＰ水平有增高趋势，但无统计学意义；皮损瘙痒的强度与血浆β－ＥＰ水平之间呈显著负相关。结论：β－ＥＰ参与银屑病的发病过程，其分泌既受中枢神经系统控制，又受皮损内炎症反应的影响。

In order to study the possible role of beta endorphin (β EP) in the pathogenesis of psoriasis, serum β EP was detected by radioimmunoassay in 51 patients with psoriasis and 32 healthy controls. The results showed that serum β EP level was markedly increased in patients with psoriasis in comparison with healthy controls. The serum β EP level was reduced when the skin lesions of the patients were cleared after treatment, however, it was still higher than in healthy controls. Although there was a tendency towards an increase of β EP in patients with precipitating factors in comparison with those without precipitating factors, their levels were not significantly different. There was a negative correlation between the intensity of pruritus and β EP levels. It is suggested that β EP involves in the pathogenisis of psoriasis. Its production and release were controlled by the central nervous system and also affected by the inflammation of skin lesions. There might be a causality between β EP levels and inflammatory reaction of skin lesions.