难治性精神分裂症不同亚型比较研究

Comparative studies of different subtypes of treatment-resistant schizophrenia

目的探讨难治性精神分裂症不同亚型的临床特征。方法对116例难治性精神分裂症患者根据阳性与阴性症状量表中评分≥4分项目数的不同为标准,将患者分为阳性亚型组、阴性亚型组、混合型组进行比较分析。结果各组间比较差异有显著性(χ2=7.569,P=0.023)。阳性亚型组较其他组首发年龄大,总病程短,住院次数少,差异显著(P<0.01或P<0.05);混合型组较其他组用药种类多,差异显著(P<0.01或P<0.05);阳性亚型组急性或亚急性起病者显著多于其他组,阴性亚型组和混合型组起病慢性。结论阳性亚型组首发年龄较大,总病程较短;混合型组使用过的抗精神病药物种类较多;阴性亚型组和混合型组起病以慢性为主,住院次数也明显比阳性亚型组多。

Objective To explore the clinical features of different subtype of treatment-resistant schizophrenia. Methods 116 treatment-resistant schizophrenics were divided into positive, negative and mixed subtype group according to numbers of item＇s score ≥4 from the Positive And Negative Symptom Scale （PANSS）. Results There were significant differences among the 3 groups（x^2=7. 569,P=0. 023）. Compared with the mixed and negative subtype groups, age at first-onset was elder, total course of disease shorter and frequencies of hospitalization fewer in the positive subtype, differences were significant（P〈0. 01 or 〈0. 05） ; compared with the other 2 groups, kinds of taken drugs were more in the mixed group and differences significant（P〈0.01 or 〈0.05） ; numbers of patients who were acute or sub-acute onset in the positive group were more. Conclusion Age at first-onset was elder and total course of disease shorter in the positive group; kinds of taken drugs were more in the mixed group;onset of the mixed and negative groups were chronic and frequencies of hospitalization more.