利培酮与氯氮平对首发精神分裂症患者血脂的影响

Effects of risperidone vs clozapine on blood-lipid of first-episode schizophrenia

目的探讨利培酮与氯氮平对首发精神分裂症患者血脂的影响。方法将118例首发精神分裂症患者随机分为利培酮组58例,氯氮平组60例,于治疗前及治疗第4、8、12w末晨间空腹采血,并进行血脂检测比较。用药剂量根据病情加减,但2w内应加至有效治疗量。结果氯氮平组8w末血脂显著上升,12w末稍有下降;利培酮组4w末血脂稍有升高,第8、12w末无显著变化。结论利培酮与氯氮平对首发精神分裂症患者血脂均有影响,但利培酮影响较轻。

Objective To explore the effects of risperidone vs clozapine on blood-lipid of first-episode schizophrenia. Methods 118 first-episode schizophrenics were randomly divided into the risperidone group （n=58） and clozapine group（n=60）, fasting bloods in the early morning were took before treatment and at the ends of 4^th, 8^th and 12^th week of treatment to compare the blood-lipid. Dosage was increased or decreased according to patients＇ condition, but should be added to effective therapeutic dose within 2 weeks. Results The blood-lipids rose at the end of 8th week and slightly dropped at the 12^th in the clozapine group;those slightly rose at the end of the 4th week and had no significant changes at the 8^th and 12^th in the risperidone group. Conclusion Both risperidone and clozapine affects blood-lipid of first-episode schizophrenia, but effects of the former is milder.