用计算机图像分析技术研究膜迷路积水

Computer image analysis in the study of endolymphatic hydrops

为探索膜迷路积水程度的判定方法，应用计算机图像分析技术对豚鼠膜迷路积水模型进行分析。采集蜗管各部（C1～C8）图像信息，根据比例因子和点计数值等，计算得出前庭膜长度及中阶面积。结果表明。①豚鼠积水模型55天之内其积水程度随时间延长而加重；②同一耳蜗底回积水程度较顶回为重，而细胞病理改变则以顶回为重。结论。采用计算机图像分析技术判断积水程度的方法客观、准确、可靠；实验中选择前庭膜长度或中阶面积均可判断积水程度，且两者之间差异无显著性。

In search for an objective method to be used to judge the extent of hydrops, computer image analysis system was used in the study on guinea pig endolYmphatic hydrops. The image infor-mation of the whole cochlea was collected, then the length of Reissener's membrane and section area of scala media were calculated based upon parameters such as ratio factors and point values. The results were as follows: 1) Hydrops observed with light microscope had no statistical difference. 2)Within 55 days postoperatively, the hydrops grew more obvious with time. 3)The hydrops was more extensive in the basal turn than in the apical turn, though more conspicuous cytopathologic change was found in the apical turn. The conclusions: 1) The current technique is objective, accurate and reliable. 2) Both the length of Reissener's membrane and section area of scala media can be used to measure the extent of hydrops.