沙眼衣原体和解脲支原体引起不育的临床观察

StudyonInfertilityCausedbyInfectionsofChlamydiaTrachomatisandUreaplasmaUrealyticum

目的：探索沙眼衣原体（ＣＴ）和解脲支原体（ＵＵ）感染对生育的影响。方法：应用单克隆抗体免疫荧光法和分离培养法，对１１９８例不育患者（不育组）及１６７例正常生育者（对照组），进行ＣＴ和ＵＵ检测。结果：不育组和对照组ＣＴ阳性率分别为２５．５％和６．６％，ＵＵ阳性率分别为３５．９％和１５．６％。两组间差异均有极显著性（Ｐ＜０．０１）。经治疗后ＣＴ和ＵＵ转为阴性者的妊娠率明显高于未转为阴性者（Ｐ＜０．０１）。结论：ＣＴ和ＵＵ的生殖道感染是造成不育的因素之一。

Objective:Toexploretheefectsofchlamydiatrachomatis(CT)andureaplasmaurealyticum(UU)infectionsonmaleandfemaleinfertility.Methods:Samplesfromcervicalcanalormaleurethraof1198infertilepatients(599couples)werestudiedandfrom167normalfertilemenandwomenservedascontrol.ThefluorescentmonoclonalantibodytechniqueandtheculturemethodwereusedforCTandUUassaysrespectively.Results:ThepositiveratesofCTandUUinfectionsininfertilegroupwere25.5%(306/1198)and35.9%(167/1198)respectively,while6.6%(11/167)and15.6%(26/167)inthecontrolgrouprespectively.Thereweresignificantdiferencesbetweenthe2groups(P<0.01).Aftertreatmentofpositivepatients,thepregnancyrateswerehigherinthosepatientsbecamenegativethanthatinpatientsremainedpositive(P<0.01).Conclusion:TheCTandUUinfectionswereoneofthefactorscausinginfertility.