川崎病血液流变学的初步探讨

Astudyonthehemorheologyofkawasakidisease

为探讨川崎病（ＫＤ）血液流变学改变，采用血液比粘度计检测了７８例ＫＤ患儿急性期与药物治疗１５天后的血粘度。结果：（１）急性期与对照组比较，全血低切粘度、血浆粘度（Ｖｐ）、血沉方程Ｋ值（ＥＳＲ－Ｋ）、红细胞聚集指数、红细胞电泳时间及纤维蛋白原（Ｆｉｂ）明显增高（Ｐ＜０．０１）；红细胞压积（ＨＣＴ）显著降低（Ｐ＜０．０１）。（２）药物治疗１５天后血液流变学指标明显改善，而Ｖｐ、ＥＳＲ－Ｋ仍增高（Ｐ＜０．０１）；ＨＣＴ仍降低（Ｐ＜０．０１）。（３）ＫＤ血粘度增高的主要原因是红细胞聚集性和Ｖｐ增高，后者与Ｆｉｂ、脂质过氧化物及免疫球蛋白呈正相关。研究表明ＫＤ患儿存在高粘、高聚、高凝、低血浓度状态。阿司匹林、复方丹参有抗粘、抗凝疗效，宜较长时间应用。

ToinvestigatethehemorheologicchangesinKawasakidisease(KD),wemeasuredthebloodviscosityin78casesinacutestageandafter15daysoftreatment.Theresultsshowedthat(1)thewholebloodlowshearviscosity,plasmaviscosity(Vp),erythrocytesedimentationrate-K(ESR-K),redbloodcelagglutinationindex,erythrocyticelectrophoresistimeandfibrinogen(Fib)increasedobviously(P<0.01),whilehematocrit(HCT)decreasedobviously(P<0.01);(2)after15daysofmedicaltreatment,theaboveindexesimprovedsignificantlyexceptforVp,ESR-KandHCT.TheresultsofthisstudysuggestedthatthehemorheologicchangesofKDwerecharicterizedbyincreasedbloodviscosityandredbloodcelaggregation.Theabovefindingssuggestedthatpro-longedadministrationofaspirinandcompoundDanshenwasindicatedfortreatmentofKD.