北京市城区儿童肺炎衣原体感染的血清流行病学调查

AseroepidemiologicalinvestigationonchlamydiapneumoniaestrainTWARinfectioninchildrenin

为了解北京市城区儿童肺炎衣原体ＴＷＡＲ（ｃｈｌａｍｙｄｉａｐｎｅｕｍｏｎｉａｌｓｔｒａｉｎＴＷＡＲ，简称ＴＷＡＲ）既往感染状况，采用微量免疫荧光试验，对５０８名２～１４岁健康儿童进行了血清ＴＷＡＲ特异性抗体ＩｇＧ的检测。既往感染的诊断标准：ＩｇＧ效价为１∶１６～１∶２５６。将受试儿童依年龄不同分为４组。检测结果显示，２～６岁ＴＷＡＲ抗体ＩｇＧ阳性率为１７．２％，～９岁为２３．５％，～１２岁２５．５％，～１４岁为４１．７％，阳性率随年龄增长而升高，各年龄组感染率差异有非常显著意义（χ２＝１７．２９９，Ｐ＜０．０１）；在性别上差异无显著意义。提示北京城区儿童ＴＷＡＲ感染率很高，临床上应重视儿童ＴＷＡＲ感染的研究。

TounderstandthestatusofTWARinfectioninchildreninBeijingcity,weinvestigat-ed508healthychildren(2～14yearsold)bydetectingthespecificserumIgGantibodyagainstTWAR.ThetiterofIgGfrom1∶16to1∶256wasconsideredasthediagnosticstandardforpreex-istingantibody.ThepositiverateofTWARinfectionwas17.2%ingroupⅠ(2～6yearsofage),23.5%ingroupⅡ(～9yearsofage),25.5%ingroupⅢ(～12yearsofage)and41.7%ingroupⅣ(～14yearsofage),respectively.Thediferencesinpositiveratebetweengroupswereverysignifi-cant(χ2=17.299,P<0.01).Thepositiverateincreasedwithageandwithoutdistinctionofsex.TheresultsindicatedthatweshouldatachgreatimportancetothehighpositiverateofTWARinfec-tioninChinesechildrenintheclinicalpractice.