2型糖尿病腔梗病变患者血脂与血液流变学变化的临床意义

The Clinical Significance of the Changes of Blood Lipids and Hemorheology in Niddm with Lacuna Infarction

目的:探讨血脂与血液流变学变化与2型糖尿病腔梗病变的关系。方法:检测68例2型糖尿病患者和45例正常对照者的血脂水平与血液流变学指标,比较糖尿病伴腔梗病变患者及不伴脑血管病变患者治疗前后的血脂与血液流变学变化。结果:2型糖尿病患者血清甘油三酯(TG)、总胆固醇(TC)、载脂蛋白B100(ApoB100)水平明显高于正常对照组(P<0.01或P<0.05),其中伴腔梗病变患者升高更为明显;经治疗后随血糖下降上述脂质水平降低,但伴腔梗病变组仍显著高于正常对照组(P<0.01)。结论:血清TG、TC、ApoB100水平升高和血液流变学变化与2型糖尿病腔梗病变有关。

Objective To study the relation between the changes of blood lipids and hemorheology in type 2 diabetes mellitus. Methods Hemorheology and the concentrations of blood lipids,including serum cholesterol （TC）, triglyceride（TG）,apolipoprotein A（ApoA）and apolipoprotein B100（ApoB100） ,of 68 type 2 diabetics and 45 healthy subjects were measured. The changes of hemorheology and the blood lipids before and after treatment, in diabetics with and without lacuna infarction,were compared respectively. Results Hemorheology and the levels of serum TG, TC,and ApoB100 in diabetics,especially in ones with lacuna infarction ,were significantly higher than those in healthy subjects（P〈0.01）. The levels of serum TG,TC,and ApoB100 in diabetics were significantly decreased,but those in diabetics with lacuna infarction were still significantly higher than in the healthy subjects （P 〈 0. 01）. Conclusion Increase in serum TG,TC and ApoB100 and hemorheology are relative to the presence of lacuna infarction in type 2 diabetes.