血脑屏障上P-糖蛋白研究进展

Advances on P-glycoprotein at blood-brain barrier

P-糖蛋白是血脑屏障上一种重要的物质外排生物转运体,参与人体多种生理病理过程,并能改变一些药物脑内动力学行为。本文综述了近年来国内外关于血脑屏障上P-糖蛋白研究的新进展,这对于认识某些中枢系统疾病、设计其治疗方案,以及开发新型P-糖蛋白调节剂都具有重要的指导意义。

P-glycoprotein is an important drug efflux transporter at the blood-brain barrier. It is involved in various physiological and pathological processes in the body and can change the kinetic behavior of drugs in the brain. This article reviews the recent advances of P-glycoprotein on the blood-brain barrier, which is helpful for us to understand some diseases of the central nervous system, devise their therapeutic regimens and develop new regulator of P-glycoprotein.