摘要
目的探讨化疗药物外渗致组织损伤的治疗方法。方法将50例住院肿瘤患者随机分为南风Ⅰ号组(20例)、喜疗妥组(15例)和如意金黄散组(15例),各组采用上述不同药物治疗。南风Ⅰ号主要由紫草、丹参、大黄、蜂房炭、冰片等按比例组成;喜疗妥、如意金黄散采用市售成药,3组均外敷损伤部位。结果治疗14d,南风Ⅰ号组疗效显著优于如意金黄散组(P<0.01)。南风Ⅰ号组、喜疗妥组、如意金黄散组治疗7d后显效病例中红肿消退时间分别为(4.4±1.5)d、(5.3±1.2)d和(5.5±1.3)d。结论南风Ⅰ号具有明显促进化疗药物外渗损伤修复的作用。
Objective To investigate the treatment options for the injury caused by chemotherapeutics extravasation. Methods Fifty patients were randomly divided into three groups： Nanfeng Ⅰ group （n = 20）, Hirudoid group （n = 15） and Ruyijinhuangsan powder group（n= 15）. Nanfeng Ⅰ was the target medicine in this research, and its major ingredients include Arnebia Root, Danshen Root, Chinese rhubarb, beehive charcoal, Borneol etc. Hirudoid and Ruyijinhuangsan were commercially available patent medicines. The medicines were applied to the injured area respectively. Results Compared with the Ruyijinhuangsan, Nanfeng Ⅰ had much better effect on day 14 （P〈0.01）. After treatment for 7 days, the time of disappearance of redness and swelling was （4.4±1.5）d,（5.3±1.2） d and （5.5±1.3） d. Conclusion The Nanfeng Ⅰ can repair the injury caused by chemotherapeutics extravasation.
基金
江苏省南通市卫生局基金资助(通卫规财[2004]39号W0431)
关键词
南风Ⅰ号
植物
药用
肿瘤
化疗
血管渗漏
Nanfeng Ⅰ
traditional Chinese medicine
tumor
chernotherapeutics extravasation
extravascular exudation
