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噬菌体展示技术在疫苗开发方面的应用 被引量：2

Development of Phage Display Technology in Vaccine Research
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摘要 介绍了噬菌体展示技术的原理、分类和特点,并综述了噬菌体展示技术应用于疫苗开发方面的进展、存在的问题及解决方法。
作者 兰芸 胡云章
机构地区 中国医学科学院/中国协和医科大学医学生物学研究所
出处 《生物技术》 CAS CSCD 2005年第5期83-86,共4页 Biotechnology
关键词 噬菌体展示技术 新型疫苗 疫苗载体 应用
分类号 Q939.48 [生物学—微生物学]
  • 相关文献

参考文献26

  • 1Smith G P. Filamcntous fusion phage: Novel expression vectors that display cloned antigens on the virion surface[ J]. Science, 1985,228(4705): 1315 -1317.
  • 2Jespers L S, Messens J H, Keyser A, et al. Surface expression and ligand - based selection of cDNAs fused to filamentous phage gene Ⅵ[J]. Biotechnology, 1995,13(4) :378 - 382.
  • 3Gao C, Mao S, Lo C H, et al. Making artificial antibodies: a format for phage display of combinatorial heterodimeric arrays[J] .Proc Natl Acad Sci U S A, 1999,96(11):6025-6030.
  • 4Sidhu S S. Phage display in pharmaceutical biotechnology[J]. Curr Opin Biotechnol, 2000,11 (6): 610 - 616.
  • 5Soltes G, Barker H, Marmai K, et al. A new helper phage and phagemid vector system improves viral display of antibody Fab fragments and avoids propagation of insert-less virions[J] .J Immunol Methods, 2003,274(1 -2):233-44.
  • 6Strobel H, Ladant D, Jestin J L. Efficient display of two enzymes on filamentous phage using an improved signsl sequence[J]. Mol Biotechnol, 2003,24(1) :1 - 10.
  • 7Malys N, Chang D Y, Baumann R G, et al. A bipartite bacterophage T4SOC and HOC randomized T4 terminase (gp17) and late sigma factor (gp55)interaction[J] .J Mol Biol,2002, 319(2) :289 - 304.
  • 8Malys N, Chang DY, Baumann R G, et al. A bipartite bacterophage T4SOC and HOC randomized T4 terminase (gp17) and late sigma factor (gp55)interaction[ J] .J Mol Biol,2002,319(2) :289 - 304.
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  • 10Wagner S, Hafner C, Allwardt D, et al. Vaccination with a human high molecular weight melanoma - associated antigen mimotope induces a humoral response inhibiting melanoma cell growth in vitro[J] .J Immunol,2005,174(2):976 - 982.

二级参考文献32

  • 1白雪帆，细胞与分子免疫学杂志，1998年，15卷，1期，1页
  • 2Smith G P. Filamentous fusion phage: Novel expression vectors that display cloned antigens on the virion surface. Science, 1985,228:315 - 317
  • 3Ren Z J, Black L W. Phage T4 SOC and HOC display of biologically active, full-length protein on the viral capsid, Gene, 1998, 215:439-444
  • 4Malys N, Chang D Y, Baumenn R G , et al. A bipartite bacteriophage T4 SOC and HOC randomized peptide display library: Detection and analysis of phage T4 terminase (gp17) andlate σ factor (gp55) interaction. J Mol Biol,2002,319: 289～ 304
  • 5Dunn I S. Assembly of function bacteriophage lambda virions incorporating C-terminal peptide or protein fusions with the major tail protein. J Mol Biol, 1995,248: 497 - 506
  • 6Jiang J, Abu-Shilbayeh L, Rao V B. Display of a porA peptide from Neisseria meningitidis on the bacteriophage T4 capsid surface. Infect Immu, 1997, 65(11): 4770- 4777
  • 7Mattews L J,Davis R,Smith G P.Immunogenically fit subunit vaccine components via epitope discovery from natural peptide libraries [J].Immunol,2002,169(2):837-846.
  • 8Malys N,Chang D Y,Baumann R G,et al.A bipartite bacterophage T4 SOC and HOC randomized T4 terminase (gp17) and late sigma factor (gp55) interaction [J].J Mol Biol,2002,319(2):289-304.
  • 9Hammond J M, Mccoy R J, Jansen E S, et al. Vaccination with a single dose of a recombinant porcine adenovirus expressing the classical swine fever virus gp55 (E2) gene protects pigs against classical swine fever. Vaccine ,2000, 18 (11 - 12):1040～ 1050
  • 10Smith G P.Filamentous fusion phage novel expression vectors that display cloned antigens on the virion surface [J].Science,1985,228:315-317.

共引文献19

同被引文献10

  • 1程玉兴,朱高红,瞿素,兰芸,胡云章,胡凝珠,高承钢,王东宝,段骞.C3d分子多表位DNA疫苗体液免疫应答的增强作用[J].中国生物制品学杂志,2007,20(4):267-270. 被引量：3
  • 2Amon R, Tarrab-Hazdai R, Steward M. A mimotope peptide-based vaccine against Schistosoma mansoni: synthesis and characterization. Immunology, 2000, 101(4): 555-562.
  • 3Maeng CY, Ryu CJ, Gripon P, et al. Fine mapping of virus-neutralizing epitopes on hepatitis B virus PreS1. Virology, 2000, 270( 1 ): 9-16.
  • 4Hirabayashi Y, Fukuda H, Kimura J, et al. Identification of peptides mimicking the antigenicity and immunogenicity of conformational epitopes on Japanese encephalitis virus protein using synthetic peptide libraries. J Virol Methods, 1996, 61( 1-2): 23-36.
  • 5Partidos CD, Stanley CM, Steward MW. Immune responses in mice following immunization with chimeric synthetic peptides representing B and T cell epitopes of measles virus proteins. J Gen Virol, 1991, 72(Pt6): 1293-1299.
  • 6Nardin EH, Calvo-Calle JM, Oliveira GA, et al. A totally synthetic polyoxime malaria vaccine containing Plasmodium falciparum B cell and universal T cell epitopes elicits immune responses in volunteers of diverse HLA types. J Immunol, 2001, 166( 1 ): 481-489.
  • 7May R J, Beenhouwer DO, Scharff MD. Antibodies to keyhole limpet hemocyanin cross-react with an epitope on the polysaccharide capsule of Cryptococcus neoformans and other carbohydrates: implications for vaccine development. J Immunol, 2003, 171(9): 4905- 4912.
  • 8Livingston B, Cfimi C, Newman M, et al. A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes. J Immunol, 2002, 168( 11 ): 5499-5506.
  • 9王丽,王桂云.在丝状噬菌体主要外壳蛋白上展示外源多肽的载体[J].分子科学学报,2000,16(3):184-187. 被引量：5
  • 10余霁,刘景晶.多表位疫苗的研究进展[J].中国生化药物杂志,2002,23(6):322-324. 被引量：4

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生物技术
2005年 第5期

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