移居高原地区后肺动脉高压的葛根素治疗

Effects of Kakkonin on Pulmonary Hypertension in Altitude Migrants

目的:了解移居高原地区后出现肺动脉高压的葛根素注射液治疗效果。方法:选择移居高原地区5年以上、无高血压病、出凝血障碍及各器官器质性疾病,排除其它原因引起的肺动脉高压、诊断为高原低氧性肺动脉高压患者238例,随机分为葛根素注射液治疗组133例,复方丹参注射液对照组105例,分别于治疗前、治疗后观察肺动脉平均压、肺血管阻力、心输出量的变化及不良反应。结果:两组均降低肺动脉平均压、肺血管阻力,但以葛根素注射液治疗组的效果更明显(P<0.01),葛根素注射液不减少心输出量,复方丹参注射液减少心输出量(P<0.05);葛根素注射液降低肺动脉平均压总有效率达96.99%,明显优于复方丹参注射液的82.86%(P<0.01)。结论:葛根素注射液能降低高原低氧性肺动高压患者的肺动脉平均压及肺血管阻力,对心输出量无明显影响,是治疗移居高原地区后出现低氧性肺动脉高压的有效药物。

Objective： To understand the treatment effects of kakkonin injection on pulmonary hypertension after migrating high altitude. Methods： 238 patients who have lived in plateau for over 5 years and were diagnosed as high altitude hypoxic pulmonary hypertension, but free hypertension, bleeding or clotting disorder and any other diseases, were selected in this study. Any pulmonary hypertension caused by other reasons was excluded. The 238 cases were divided randomly into two groups. The therapeutic group （ 133 cases） was given kakkonin injection. The control group （ 105 cases） was given co - danshen root injection. We observed the mean pulmonary artery pressure, pulmonary artery resistance, variation of the kinemic and the adverse reaction respectively before and after the treatment. Results： We found that both the two groups have reduced the former two indices, but the therapeutic group has more significant effect （P 〈0. 01 ）. The control group reduced the kinemic while the therapeutic group not （ P 〈 0. 05）. The total efficiency rate of the kakkonin injection was 96.99% compared with the complex danshen root injection 82.86% （P 〈0. 01 ）. Conclusions： The kakkonin injection can reduce the mean pulmonary artery pressure and the pulmonary artery resistance of the high altitude hypoxic pnlmonary hypertension patients, while it has no significant effect ion on reducing the kinemic. It is an effective drug for the high altitude hypoxic pulmonary hypertension.