摘要
为探讨糖尿病人血IGF—1水平变化并分析其相关因素,本文作者检测了20名正常人、46例糖尿病人(其中IDDM9例,NIDDM 37例)的血IGF—1、血糖、糖化血红蛋白、胰岛素、生长激素水平,并分析了血清IGF—1与年龄、血糖、糖化血红蛋白、胰岛素、生长激素等之间的相关性,结果发现:(1)IDDM病人血清IGF—1水平明显低于正常人以及NIDDM病人,NIDDM病人的IGF—1水平与正常人接近;(2)正常人血IGF—1水平与年龄、血糖、糖化血红蛋白、胰岛素之间无相关性;糖尿病人血IGF—1水平与年龄、血糖明显相关,其中NIDDM病人的血IGF—1与年龄及糖化血红蛋白呈负相关,与生长激素呈正相关。
To investigate the change of IGF-1 level in diabetics and analyse its correlated factors,twenty healthy volunteers and forty-six diabetic patients were selected. The diabetics were divided into IDDM group and NIDDM group according to the diagnostic criterion of WHO. After the measurement of serum FBG. HbAlc,Insulin,GH and IGF-llevel, we calculated the correlation index between the IGF-llevel and other data. It was concluded that(1)In IDDM group,serum IGF-1 level was decreased remarkably than that of the normal control group and NIDDM group. In NIDDM group,there was not significant change in serum IGF-1 level . (2)In healthy volunteer group,there was no releutionship between the IGF-1 level and age,FBG,HbAlc insulin levels. The same results could be seen in IDDM group. But in NIDDM group serum IGF-1 lever was negatively correlated with age,HbAlc, and positively correlated with GH level. As a whole,IGF-1 was negatively correlated with age and FBG in Diabetics.
