Intercedenol A,B,二色桌片参皂苷降解的两个新三萜苷元

Intercedenol A and B,two new triterpenoid aglycones from the acid hydrolysis of the glycoside mixture of the sea cucumber Mensamaria intercedens

目的研究二色桌片参皂苷苷元的结构。方法采用15%硫酸水解二色桌片参总皂苷制备二色桌片参皂苷的苷元,应用多种色谱技术进行分离纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果分离并鉴定了2个三萜类化合物:3β-羟基-16β-乙酰氧基-9,22E,24-三烯-海参烷(Ⅰ),3β-羟基-16β-乙酰氧基-8,22E,24-三烯-海参烷(Ⅱ)。结论2个化合物均为新化合物。

Objective To study the aglycone of the saponins from Mensamaria intercedens. Methods Complete acid hydrolysis of the glycoside mixture of the sea cucumber with 15% H2SO4afforded an aglycone product that was separated by multichromatography and their chemical structures were elucidated by chemical and spectral analyses. Results Two compounds were obtained and identified as 16β-acetoxy-9 （11）, 22 （23） E, 24 （25）-3β-hydroxyholost （ Ⅰ ）, 16β-acetoxy-8 （9）, 22 （23） E, 24 （25）-3β-hydroxyholost （ Ⅱ ）. Conclusion Two compounds are new triterpenoids.