温敏性壳聚糖凝胶的阿霉素药物体外缓释研究

Studies on the controlled drug delivery system of thermosensitive chitosan-based hydrogel containing doxorubicin in vitro

目的壳聚糖辅以甘油磷酸钠制成温敏性凝胶,将该温敏性凝胶用作阿霉素药物载体并观察其缓释特性。方法制备负载阿霉素的温敏性壳聚糖凝胶,建立体外持续流动释放系统,应用紫外分光光度法测定阿霉素的含量,对该载药凝胶进行体外的缓释实验。结果制备了负载阿霉素的温敏性壳聚糖凝胶,并得到了其缓释曲线。结论该温敏性凝胶能够用于负载并释放阿霉素,这为改善阿霉素使用途径提供了实验基础。

Objective To study the preparation of temperature-sensitive hydrogel system, which is based on chitosan added by β-glycerophosphate and is used to deliver the doxorubicin, and its delivery property. Methods The doxorubicin-containing temperature-sensitive hydrogel system based on chitosan was prepared： ultraviolet spectrophotometry was used to measure the content of doxorubicin; the drug release by the sustained release system was observed in vitro. Results Doxorubicin-containing temperature-sensitive hydrogel system based on chitosan was prepared and the release curve was obtained to express its delivery property. Conelusion The temperature-sensitive system based on chitosan can be used to deliver doxorubicin. The results provided the experimental basis for improvement of the delivery of doxorubicin.