红细胞流变性异常在高血压病程中的作用

Thr Effect of Erythrocyte Aggregability on the Process of Essential Hgpertension

应用动物实验并参照临床研究，探讨红细胞流变性异常对血压的影响及其在高血压病程中的作用。结果表明；急性红细胞聚集性增强可显著增加动物血压和心率，使血浆前列环素含量减少和血管内皮细胞结构受损。高血压病患者的全血高、低切粘度，红细胞聚集性（ＲＡＩ）显著高于正常人。提示：短期红细胞聚集性异常不仅可通过增加全血粘度使循环阻力升高而升高血压；还可通过损伤血管内皮细胞、降低舒张血管活性物质含量使血压升高。长期流变学异常可能使小动脉壁结构重构、管腔狭窄，进而增加外周血管阻力而致高血压形成。

In order to investigate the effect of erythrocgte aggregability on arterial pressure and its mechanism, we have done animal experiment and clinical studies. The results showed that acute intensified erythrocyte aggregability could cause the rising of arterial pressure and heart rate significantly,and it could destroy the vascular endothelial cell and decrease the content of serum 6-keto -PGF1a. The red cell aggregability index (RAI) and the whole blood viscosity under high and low shear stresses in patients with essential hypertension were higher than those in normal man (P<0. 05~0. 001). These suggested that the short term abnormality of erythrocyte rheology could elerate the arterial pressure through raising the whole blood viscosity. Meanwhile, intensified erythrocyte aggregability could destroy the endothelial cell and cause remodelling of the small artery,and hence it could elevate the peripheral vessel resistance.