谷胱甘肽转移酶μ基因缺失与老年性白内障发病关系的探讨

AstydtonrelationshipbetweenglutathioneS┐transferaseμgenedeletionandsenilecataractsuscepti┐bility

目的探讨谷胱甘肽转移酶μ（ｇｌｕｔａｔｈｉｏｎｅＳ－ｔｒａｎｓｆｅｒａｓｅμ，ＧＳＴμ）基因缺失与老年性白内障发病的关系。方法采用多聚酶链反应（ｐｏｌｙｍｅｒａｓｅｃｈａｉｎｒｅａｃｔｉｏｎ，ＰＣＲ）方法，对５９例老年性白内障患者及１１２例健康对照者进行ＧＳＴμ基因检测。结果老年性白内障患者ＧＳＴμ基因缺失率达６９．５％，明显高于对照组的５０．９％（Ｐ＜０．０５）。按吸烟与否分析表明，吸烟的白内障患者ＧＳＴμ基因缺失率有高于对照组的趋势。由于本研究样本量较小，吸烟的白内障患者ＧＳＴμ基因缺失率虽达到７２．４％，但与对照组比较差异无显著性（Ｐ＞０．０５）。结论老年性白内障的发病与ＧＳＴμ基因缺失密切相关，该基因缺失可能是个体易患白内障的遗传因素之一。

ObjectiveTostudytherelationshipbetweenglutathioneS-transferaseμ(GSTμ)genedeletionandsenilecataract(SC)susceptibility.MethodPolymerasechainreaction(PCR)methodwasusedtoinvestigatetheratesofGSTμgenedeletionin59caseswithSCand112healthycontrols.ResultsTherateofGSTμgenedeletionincaseswithSCwas69.5%whichwassignificantlyhigherthanthatofthecontrols,50.9%(P<0.05).AnanalysisstratifiedbysmokingandnonsmokingshowedthatGSTμgenedeletionrateinsmokingsubjectswithSCwashigher.Becauseofthesmalsam-plesizeofthisstudy,althoughtherateofGSTμgenedeletioninsmokingsubjectswithSChasreached72.4%,thatisnotsignificantlydiferentfromthatofthecontrolsstatisticaly(P>0.05).ConclusionSCcorelateswithGSTμgenedeletionandGSTμgenedeletionisoneofthehereditaryfactorsforsus-ceptibilitytoSC.