麻疹疫苗免疫人群隐性感染的观察研究

Study on the Subcinical Infection of the Recipients of Measles Vaccine

对分布在三个班级的在12年前麻疹疫苗免疫成功者71人,暴露于自然麻疹后隐性感染情况的观察,显示:①麻疹疫苗免疫人群中麻疹的隐性感染普遍存在,三个班级的隐性感染率波动在18.5%～75.0%,平均为45.1%。②麻疹疫苗免疫人群麻疹隐性感染的血凝抑制抗体滴度范围在<1:2～1:16,高峰在1:2和/或1:4水平。因此麻疹疫苗免疫人群在暴露时隐性感染率的高低主要取决于该人群中麻疹血凝抑制抗体1:2～1:4水平者的比重。③麻疹隐性感染的流行病学意义,在于它客观上起着巩固麻疹疫苗免疫人群的免疫水平的作用。

Through observation to subclinical infection of the 71 children who had been inoculated against measles 12 years ago and then exposed to natural measles from three classes at a primary school, we have noticed: (1)Subclinical infection did exist among the crowd who were inoculationed against measles; The rate of subclinical infection of the three classes was between 18.5%—75.0%, with an average of 45.1%. (2) The level of the HI Ab titer was between 1: 2—1:16.The peak level was between 1:2 and/or 1:4. So the rate of subclinical infection who had been inculationed against measles but later exposed to natural measles would depend on the proportion of those whose titer of HI Ab was 1:2—1:4 in the crowd. (3) The epidemiological significance of subdclinical measles infection lies in that it can actively keep and consolidate the level of immunity to certain extent in a crowd who had been inoculationed against measles.