河北省肾综合征出血热疫区分布及血清学分型研究

Study on the Geographic Distribution and Serological Typing of HFRS in Hebei Province

1986～1993年连续肾综合征出血热(HFRS)监测,宅区共布鼠夹108 934夹次,各地形区鼠密度4.6%～12.2%,褐家鼠占60.0%以上,其汉坦病毒(HV)抗原携带率1.3%～7.5%,远高于其它种鼠。带病毒褐家鼠密度同发病率呈显著性正相关。129例病人血清血凝抑制试验(HI)分型,家鼠型病人占89.1%,冀东和中部平原含少量姬鼠型病人,占1.6%。1980～1993年全省共发病9 609例,平原区是HFRS的疫区。分析了HV在河北省的传播路径。指出1、2月灭宅区鼠和重点疫区接种HFRSⅡ型疫苗是降低发病率的关键。

Surveillance on the HFRS had been carried out during the period of 1986-1993. Rodent density ranged from 4.6%-12.2% with R. norvegieus exceeding 60% in all kinds of rodents. HV antigen carrier rate of R, norvegicus was 1.3%-7.5%, much higher than that among other rodents. A significantly positive correlation had been observed between the HFRS morbidity and. the R. norvegicus density. Of 129 specimens from HFRS patients, 89% belonged to the type of SEOV. In the eastern and centre Parts of Hebei plain, HTNV occupied 1.6%. A total number of 9 609 HFRS patients had been identified during the period of 1980-1993. The plain area in Hebei province was recognized as the major epidemic area. The key measure for decreasing the HFRS morbidity was deratizationin in the residential area in January and February and immunization with HFRS inactivated vaccine.