射频对犬前列腺α_1－肾上腺素能受体的影响

Effect of radiofreguency treatment on canine prostate alpha-1 adrenocepetor and It's clinical significance

为了探讨α１－肾上腺素能受体（以下简称α１－受体）变化在射频治疗前列腺增生症（ＢＰＨ）中的意义，采用放射配体法测定射频治疗前后犬前列腺α１－受体的变化。结果表明：治疗后前列腺组织中α１－受体浓度为０．４９８±０．０５ｆｍｏｌ／ｍｇ，明显低于治疗前的０．７６６±０．０４ｆｍｏｌ／ｍｇ（Ｐ＜０．０５）。并对α１－受体的变化在射频治疗ＢＰＨ中的意义进行了讨论。认为射频治疗可以破坏前列腺组织中α１－受体，从而解除因前列腺平滑肌收缩而引起的动力性梗阻，改善患者症状。

Radioligand receptor binding method was used to assay the alpha-l adrenoceptor density (Bmax)of the prostate samples of male dogs before (controled group) and after radiofrequency hyperthermia treated(treated groups).Saturation experiments were performed in tissue homogenates using[￣3H]-prazosin(36 Ci/mmol).The receptor density in controlled and treated groups were 0.766±0.04(fmol/mg) and 0.498±0.05 (fmol/mg),respectively(P <0.05).The function and significance of the adrenoceptor's decrease in BPH hyperthermia were discussed.