肌松Ⅱ号胶囊对兔膝骨性关节炎关节液中NO水平的影响

Effects of Jisong Capsule Ⅱ on NO in the Synovial Fluid of Rabbit OA

目的研究肌松Ⅱ号胶囊对骨关节炎家免关节液中NO和滑膜组织NOS的影响，探讨其治疗OA的机制。方法应用关节制动的方法复制OA模型，12只造模成功的中国家兔，随机分为肌松组（A组）、对照组（B组）。A组用肌松胶囊和手法治疗，B组仅予以手法治疗，疗程为1月。检测治疗前后关节液中NO和治疗后滑膜组织中NOS的含量。结果治疗后肌松组NO和NOS水平均低于对照组（P〈0．05），各组NO的含量较治疗前均明显下降（P〈0．01）。结论肌松Ⅱ号胶囊能抑制滑膜组织NOS的活性，减少关节液中NO的含量，而治疗膝骨性关节炎。

Objective To study the effects of Jisong Capsule Ⅱ on NO in the synovial fluid and NOS in the synovium of rabbit Ostoearthritis（OA） ,and investigate it‘s mechanism of treating OA. Methods 12 rabbits,immobilized in full extension for up to six weeks,were divided into two groups：group A and group B at random. Group A was treated with Jisong Gapsule Ⅱ and manipulation,group B was treated with manipulation only,and the course of NOS was detected only after treatmint. Results After treatment course, No and NOS level of group A was lower than that of group B （ p 〈 0.05） ; And the level of NO deelined signifieantly compared with that of before treatment in two groups（ p 〈 0.01 ）. Conclusion Jisong Capsule Ⅱ ean significantly decrease the contend of NOS in the synovium,and yet reduce the level of NO in the synowial fluid,so as to achieve the therapeutic effect on OA.