平阳霉素碘油乳剂介入治疗原发性大肝癌

Clinical research on pingyangmycin lipiodol emulsion hepatic arterial embolization for primary hepatocellular carcinoma

目的评价平阳霉素(PYM)+丝裂霉素超乳化碘油乳剂(PMLE)介入栓塞对原发性大肝癌的临床疗效.方法对34例原发性大肝癌肝动脉注入PMLE,以前期56例原发性大肝癌以丝裂霉素超乳化碘油乳剂(MLE)作对照,比较两组栓塞后肿瘤体积变化.结果栓塞后1～3个月两组肿瘤体积均明显缩小,PMLE组显著于MLE组(P＜0.05).结论平阳霉素介入治疗原发性大肝癌有显著疗效.

Objective To evaluate the devascular effect（DC） of pingyangmycin- mitomycin-lipiodol emulsion （PMLE） embolization on tumor vessel of primary hepatocellular carcinoma（PHC）. Methods Hepatical embolization was performed with PMLE（ n = 34） in PHC,and mitomycin-lipiodol emulsion（MLE） as a contrast group（ n = 56）. The changes of tumor size were reviewed and compared. Results The tumor size of two groups decreased after 1 3 months of the procedure,and it was more significant in the PMLE groups（P 〈 0.05）. Conclusion PMLE has obvious DE and detumor effect,and is effective to the management of primary hepatocellular carcinoma.