副溶血性弧菌致病性及耐药性分析

Pathogenicity and drug resistance analysis of V. Parahaemolyticus

目的了解宿州地区副溶血性弧菌的肠道感染情况。方法对两年中分离到的302株副溶血性弧菌进行溶血素和抗生素敏感性测定,并对患者的临床资料进行统计分析。结果两年中共检测急性腹泻患者的粪便标本3165份,检出副溶血性弧菌302株,检出率为9.5%。其中脲酶阳性48株,占副溶血性弧菌的15.9%。以7～9月副溶血性弧菌检出最多(252株),占副溶血性弧菌总检出数的83.4%。对302株副溶血性弧菌溶血素检测结果表明,耐热溶血素(TDH)阳性213株,占70.5%;不耐热溶血素(TRH)阳性43株,占14.2%。副溶血性弧菌对痢特灵(FR)的耐药率为66.3%,其次是氨苄西林(AMP),为61%。结论脲酶阴性与阳性副溶血性弧菌均有较强的致病性。

Objective To survey the status of intestinal infections by V. parahaemolyticus in the local area. Methods The sensitivity of antibiotics and hemolysin of isolated 302 strains of V. parahaemolytieus were detected during two years,and the clinical data were analyzed statistically. Results 302 strains of V. parahaemolyticus were found in 3 165 stool specimens of the patients with acute diarrhea. The positive rate was 9.5%. There were 48 strains with positive urease accounting for 15.9% of V. parahaemolytieus. Most（252 strians）of them were found from July to September, accounting for 83.4 % of V. parahaemolytieus. Hemolysin monitoring showed 213 strains of V. parahaemolytieus with positive TDH,accounting for 70.5%. 43 strains with negative TDH（14. 2%）. Drug resistance of V. parahaemolyticus to FR and AMP were 66.3%, 61% respectively. Conclusion V. Parahaemolyticus with positive and negative urease have stronger pathogenicity.