米力农对充血性心力衰竭患者BNP的影响

The Effect of Milrinone on Heart Failure Patients and Its Influence to BNP

目的观察米力农治疗重症充血性心力衰竭(CHF)的临床疗效及其对脑钠素(BNP)的影响.方法82例重症充血性心力衰竭患者,随机分为米力农组(42例)和对照组(40例),对照组予以常规治疗,米力农组在常规治疗基础上静脉应用米力农7d,用放射免疫法测定血浆BNP在治疗前后的改变.结果治疗后米力农组BNP水平明显降低,并明显低于对照组(P＜0.01).心功能改善1～2级,药物副反应少,患者耐受性好.结论米力农治疗CHF疗效较好,并能在一定程度上改善心衰患者的神经内分泌失调.

Objectives To observe the effect of milrinone on heart failure patients and its influence to the plasma level of brain natriuretic peptide （BNP）. Methods 82 patients with CHF were enrolled in the study. The patients were randomly divided into milrinone group （42 cases）and control group （40 cases）. The control group were treated with conventional drugs. Milrinone group were given milrinone intravenous 7 days. The plasma level of BNP was investigated before and after the treatment. Results The sig- nificant-effect rate was higher in milrinone group than control group. The cardiac function improved by 1-2 grades after milrinone treatment. The plasma level of BNP in milrinone group was significantly declined than before and control group. Conclusions Milrinone was effective and safe for CHF and could decreased BNP plasma level.