尼群地平衍生物Ⅵ对豚鼠乳头状肌收缩力的影响

Effect of nitrendipine derivative Ⅵ on the contractive force of guinea pig papillary muscles

对比观察了尼群地平衍生物Ⅵ（ＮＩＴＤⅥ）及尼群地平（ＮＩＴ）对豚鼠乳头状肌收缩力的影响。结果表明，ＮＩＴＤⅥ及ＮＩＴ分别从３×１０－７及３×１０－８ｍｏｌ／Ｌ开始抑制豚鼠乳头状肌收缩力，当其浓度分别增至３×１０－５及３×１０－６ｍｏｌ／Ｌ时，心肌收缩力明显减弱，甚至消失。在相同浓度下，ＮＩＴ对豚鼠乳头状肌收缩力的抑制作用明显强于ＮＩＴＤⅥ。提示：ＮＩＴＤⅥ及ＮＩＴ均可减弱心肌收缩力，且ＮＩＴＤⅥ的抑制作用弱于ＮＩＴ。

This paper is about comparative observation of the effect of nitrendipine derivative Ⅵ(NITD Ⅵ)and nitrendipine(NIT)on the contractive force(FC)of guinea pig papillary muscles.The result showed that the FC of guinea pig papillary muscles began to be inhibited when 3×10-7 and 3×10-8 mol/L of NITD Ⅵ and NIT were given respectively,and when the concentration reached 3×10-5 and 3×10-6 mol/L respectively,the FC of the cardiac muscles obviously decreased,even disappeared.With the same concentration,the inhibitory effect of NIT on the guinea pig papillary muscles was apparently stronger than that of NITD Ⅵ.These results suggested that both NITD Ⅵ and NIT could weaken the FC of the cardiac muscles,and the inhibitory effect of NITD Ⅵ may be weaker than that of NIT.