乙型肝炎病毒血清标志物定量检测与血清ALT的关系

Quantitative detection of Serum Marker With Hepatitis B Virus and its relationship with Alanine Transaminase

目的 探讨慢性乙型肝炎病毒（HBV）血清标志物定量检测的意义及与丙氨酸氨基转移酶（ALT）的关系。方法 对237例慢性乙型肝炎病人的病毒血清标志物（HBsAg，HBsAb；HBeAg、HBeAb，HBcAg，HBcAb）进行定量检测，并测量HBsAg，HBeAg与丙氨酸氨基转移酶的关系。结果 HBsAg的浓度与ALT的浓度不具相关性，HBeAg的浓度与ALT的浓度呈相关。HBeAg阳性组的ALT与阴性组的ALT比较有非常显著性差异（P〈0．01）。73％乙肝病人病毒标志物特征为HBsAg，HBeAb，HBcAb阳性。结论 HBeAg浓度与肝功能ALT呈负相关，大多数慢性乙肝病人的ALT处于正常。

Objective To explore the significance of quantitative detection of serum marker with HBV and its relationship with the degree of hepatocyte injury in patients infected with HBV. Methods The contents of HBV serum indexes such as HBsAg, HBsAb, HBeAg, HBeAb, HBcAg, HBcAb and ALT were detected by RIA, IRMA and auto-biochemical instrument in 237 patients with HBV. Results The concentration of HBsAg had no correlation with ALT, but the contents of HBeAg had a significant negative correlation with ALT （r=-0.524）; and 73% people with HBV infection were characterized by HBsAg （＋）, HBeAb （＋） and HBcAb （＋）. Conclusion Serum level of HBeAg has negative correlation with ALT level; serum level of ALT in most people with HBV remains in normal range.