肺癌患者血栓前状态的研究

Study on Prethrombotic State in Lung Cancer Patients

对１０４例肺癌的血小板表面α－颗粒膜蛋白、血浆血管性假血友病因子、凝血酶原、凝血酶、抗凝血酶Ⅲ进行了测定。结果分别有６６．４％、８１．７％、６２．５％的患者α－颗粒膜蛋白分子数、血管性假血友病因子及凝血酶浓度较正常升高，早晚期差异显著（Ｐ＜０．０５）。９．６％患者抗凝血酶Ⅲ含量和活性减低。追踪观察１．５年发现，有无血栓前状态其转移率和死亡率有显著差异（Ｐ＜０．０５）。由此可见肺癌常伴血栓前状态，其程度与病期及预后密切相关。

Determination of molecule number of platelet surface α-granule membrane protein(GMP(140)),pfothrombin,Von Willebrand factor(VWF),thrombin concentration,antithrombin(ATⅢ)antigen and activity in plasma was made in 104 Patients with lung cancer.The results demonstrated that GMP(140)increased in 66.4%of patients,VWF antigen present in 81.7%and elevated thrombin concentration in 62. 5%. There was significant difference between advanced and early stages of diseases(P<0. 05).AT Ⅲ antigen and activity decreased in 9.6%of patients.After one and half years follow-up study,the metastatic rate and motality in patient of normal coagulable state were all lower than those in Patients of Prethrombotic state(P<0. 05).These data suggest that most patients with lung cancer are often associated with prethrombotic state.The severity of this state is cosely related to duration of disease and prognosis.