120例临床真菌感染的分析

Analysis of 120 fungus Infection cases

目的分析真菌感染的危险因素,为临床预防和减少真菌感染提供参考.方法对2003年1～12月间真菌感染的120份病例进行回顾性调查,同时随机抽取87例同期非真菌感染住院病例作为对照组.结果调查的真菌感染病例中,真菌感染标本来源最多者为呼吸道分泌物,原发基础病也以呼吸系统的疾病为多,占41.7%;患者年龄构成60岁以上者占70%;感染前广谱抗菌素使用超过7 d者占52.5%;各种插管占15%,均明显高于对照组(P＜0.05).结论年龄超过60岁,严重基础疾病、高效广谱抗菌素的应用、插管等侵袭性操作均为临床真菌感染的危险因素.临床应针对上述因素有重点地加以预防.

Aim Through analyze risk factors of infection with fungi to prevent and reduce the infection with fungi in clinic. Methods Clinical data of 120 patients with fungi infection from Jan 2003 to Dec were investigated retrospectively. At same time, chosen 87 patients with other infection as control group ramdomly. Results In the patients＇age beyond 60, there was significent difference between the investigative groups and cntrol group （84/120 vs 39/87, P 〈 0.05 ）. In the aluration of antibiotic application more 7 days there was significent fifference between two groups（ 63/120 vs 30/87,P 〈 0.05 ）. The significent difference was found in the use of invasive operation between two groups （18/120 vs 3/87 ,P 〈0.05）. No significent diference was found in the use of immunosuppressent （26/120 vs 14/ 87,P 〉 0.05 ）. Conclusion Age beyound 60, severe underlying diseases, long term antibiotic application and invasive operation were the main risk factors of fungi infection.