伊班膦酸钠治疗肺癌骨转移疼痛28例

Therapeument of Ibandronate in 28 Patients with Bone Metastases from Pulmonary Cancer

目的观察和评价伊班膦酸钠治疗肺癌骨转移疼痛的疗效与安全性.方法共28例确诊为肺癌骨转移疼痛的患者,均给予伊班膦酸钠4 mg加0.9%氯化钠注射液或5%葡萄糖注射液500～750 mL静脉滴注,滴注持续时间＞2 h,每4周1次,连续治疗2次后评价疗效.结果治疗两次后止痛有效率(疼痛缓解＞50%,缓解持续时间达到4周者所占比例)为75.0%,不良反应较轻微,患者可以耐受.结论伊班膦酸钠对肺癌骨转移引起的疼痛具有良好的止痛效果,且不良反应轻,值得临床推广.

Objective To evcluate the analgesic effect of ibandronate and its adverse drug reaction （ADR） in patients with bone metastases from pulmonary cancer. Method 28 patients diagnosed hone metastases from pulmonary cancer were given 4 mg ibandronate in 500 -750 mL sodium chloride injection or 5% glucose injection, iv, for more than 2 h infusion, 1 time every 4 wk for 8 wk. Results The analgesic rate of ibandronate was 75.0%. And the rate of ADR was relatively low, for example, fever. Conclusion Ibandronate which is kind of hone absorption inhibitor is effective and safe for patients with metastatic bone tumor in analgesia treatment.