血浆脂蛋白(a)水平与冠状动脉病变的相关性研究

Correlation between Lp(a) and coronary artery disease

目的:探讨血浆脂蛋白(a)水平与冠状动脉病变的程度与范围的相关性,评价对冠心病危险因素的预测价值。方法:选择行冠脉造影术的患者560例,分为冠心病组(364例)和对照组(196例),测定脂蛋白(a)水平。结果:冠心病组脂蛋白为(220±140)mg/L,对照组为(180±128)mg/L,2组比较差异有统计学意义(P<0.01); 脂蛋白(a)水平与冠状动脉狭窄程度呈正相关关系(r=0.56,P<0.01)。结论:脂蛋白(a)与冠状动脉粥样硬化程度及范围相关。

Objective： To evaluate the correlation of Lp（a）to the extent, everity of coronary artery disease. Methods： In 560 patients undering coronary angiography, Lp（a） were measured with usual procedures. Results. Lp（a） in experimented group （220± 140） mg/L were significantly higher than that in control group （180±128） mg/L There was a positive association between Lp（a） and the extent and severity of coronary artery disease. Conclusions： Elevated Lp（a） correlated well with the extent, severity of the coronary artery disease.