乙型肝炎后肝硬化病人凝血功能变化指标检测的临床意义

Detection of PT,APTT and Fbg in Patients with Post hepatitis B Cirrhosis

目的研究乙型肝炎后肝硬化病人凝血功能变化与Child-Pugh肝功能分级的关系。方法测定88例乙型肝炎后肝硬化病人与28例健康者的凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、纤维蛋白原。结果乙型肝炎后肝硬化病人存在不同程度凝血功能障碍,PT、APTT、Fbg水平与对照比较,差异有非常显著性,检测结果显示A、B、C级之间PT、APTT、Fbg相互比较,差异有非常显著性。结论乙型肝炎后肝硬化病血浆PT、APTT、Fbg,可作为判定病变程度的指标,可对预后作出有价值的判断,为治疗提供依据。

[ Objective] To study the relationship between blood coagulation function changes and Child- Pugh liver function grades among patients with post hepatitis B cirrhosis. [Methods] PT, APTT and Fbg of 88 patients and 28 healthy people were determined respectively. [Results] Patients with post hepatitis B cirrhosis had various degrees of dysfunction of blood coagulation. Significant difference was found in PT, APTT and Fbg compared with that of the control group. Significant difference was also found among different grades. [Conclusion] The plasma PT, APTT and Fbg are useful markers for determining the degrees of the disease, it also provide basis for the treatment.